Should my GLP-1 Sublingual / Oral medication be refrigerated? February 20, 2024 21:09 Updated No. Sublingual medication does not need to be refrigerated to maintain its effectiveness. Related articles Is Sublingual GLP-1 as effective as injectable GLP-1? Should my GLP-1 medication be refrigerated? What is a Sublingual or Oral medication? Why is my vial only half full? What is compounded semaglutide, and how can it help with weight loss?